Short-term effects of Garcinia cambogia extract on the pharmacokinetics of lamotrigine given as a single-dose in Wistar rats

Food Chem Toxicol. 2019 Jun;128:61-67. doi: 10.1016/j.fct.2019.03.051. Epub 2019 Mar 30.

Abstract

Garcinia cambogia supplements are widely used for weight loss. Knowing that epilepsy patients are at greater risk of developing overweight/obesity, the investigation of herb-drug interactions involving antiepileptic drugs of narrow therapeutic index is fully justified. This work was planned to assess potential pharmacokinetic-based interactions between G. cambogia extract and lamotrigine (LTG) through two independent pharmacokinetic studies. In the first study (co-administration study), rats were orally co-administered with a single-dose of G. cambogia extract (821 mg/kg) and LTG (10 mg/kg). In the second study (pre-treatment study), rats were orally pre-treated for 14 days with G. cambogia extract (821 mg/kg/day), being LTG administered (10 mg/kg) on the 15th day. Rats of the control groups received water instead of the extract. Following LTG administration, blood samples were collected until 96 h post-dose, and plasma LTG concentrations were determined and submitted to a non-compartmental analysis. Globally, no statistically significant effects were identified in the co-administration study of G. cambogia extract and LTG. In the 14-day pre-treatment study, a statistically significant decrease in the rate of systemic exposure to LTG and an increase of apparent volume of distribution were found. Even so, a minor or no clinical impact is expected from the administration of G. cambogia dietary supplements and LTG.

Keywords: Garcinia cambogia; Herb-drug interaction; Herbal supplements; Lamotrigine; Pharmacokinetics; Rats.

MeSH terms

  • Animals
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / blood
  • Anticonvulsants / pharmacokinetics*
  • Area Under Curve
  • Body Weight / drug effects
  • Dietary Supplements
  • Garcinia cambogia / chemistry*
  • Half-Life
  • Herb-Drug Interactions*
  • Lamotrigine / administration & dosage
  • Lamotrigine / blood
  • Lamotrigine / pharmacokinetics*
  • Male
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Rats, Wistar

Substances

  • Anticonvulsants
  • Plant Extracts
  • Lamotrigine