Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jul;42(7):549-559.
doi: 10.1007/s12272-019-01146-9. Epub 2019 Apr 2.

T Helper 17 (Th17) Cells and interleukin-17 (IL-17) in Cancer


T Helper 17 (Th17) Cells and interleukin-17 (IL-17) in Cancer

Seon Hee Chang. Arch Pharm Res. .


Th17 cells are a specialized subset of CD4+ T cells that are essential in driving inflammation during autoimmune disease and infection through a signature cytokine IL-17. Th17 cells have been found in various human cancers. The function of these cells in cancers is highly context-dependent; both tumor-promoting and tumor-suppressing activity have been reported. IL-17 and IL-22, Th17-derived cytokines, influence the tumor microenvironment by directly promoting transformed cell properties and neighboring stromal cell activity. These cytokines are also involved in regulation of the immune system by modulating the activities of myeloid cells and T cells. These findings suggest that Th17 cells and their cytokines are a key mediator of cancer development, representing a potential target for cancer therapy. Herein, I review recent preclinical studies on the function of Th17 cells and IL-17 in cancer and discuss possible therapeutic approaches to harness Th17 cells for cancer immunotherapy.

Keywords: Cancer; IL-17; Immunotherapy; Inflammation; Oncogene; Th17 cells.

Similar articles

See all similar articles

Cited by 2 articles

  • TYK2 in Tumor Immunosurveillance.
    Karjalainen A, Shoebridge S, Krunic M, Simonović N, Tebb G, Macho-Maschler S, Strobl B, Müller M. Karjalainen A, et al. Cancers (Basel). 2020 Jan 8;12(1):150. doi: 10.3390/cancers12010150. Cancers (Basel). 2020. PMID: 31936322 Free PMC article. Review.
  • Lung Cancer Heterogeneity in Modulation of Th17/IL17A Responses.
    Armstrong D, Chang CY, Lazarus DR, Corry D, Kheradmand F. Armstrong D, et al. Front Oncol. 2019 Dec 10;9:1384. doi: 10.3389/fonc.2019.01384. eCollection 2019. Front Oncol. 2019. PMID: 31921642 Free PMC article. Review.

LinkOut - more resources