Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals

IUBMB Life. 2019 Jun;71(6):749-759. doi: 10.1002/iub.2040. Epub 2019 Apr 2.


Previous decades have seen an explosion in our understanding of protein kinase function in human health and disease. Hundreds of unique kinase structures have been solved, allowing us to create generalized rules for catalysis, assign roles of communities within the catalytic core, and develop specific drugs for targeting various pathways. Although our understanding of intracellular kinases has developed at a fast rate, our exploration into extracellular kinases has just begun. In this review, we will cover the secreted protein kinase families found in humans, bacteria, and parasites. © 2019 IUBMB Life, 71(6):749-759, 2019.

Keywords: Fam20C; bacterial effectors; parasite kinases; protein kinases; secretory pathway.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacteria / enzymology
  • Biological Transport / genetics*
  • Humans
  • Mammals / genetics
  • Parasites / enzymology
  • Phosphorylation / genetics*
  • Protein Kinases / classification
  • Protein Kinases / genetics*
  • Substrate Specificity


  • Protein Kinases