Novel Quinolylnitrones Combining Neuroprotective and Antioxidant Properties

ACS Chem Neurosci. 2019 Jun 19;10(6):2703-2706. doi: 10.1021/acschemneuro.9b00152. Epub 2019 Apr 9.


We describe here the preparation, neuroprotective analysis, and antioxidant capacity of 11 novel quinolylnitrones (QN). The neuroprotective analysis of QN1-11 in an oxygen-glucose deprivation model, in primary neuronal cultures, has been determined, allowing us to identify QN6 as a very potent neuroprotective agent, showing significant high value at 0.5 and 10 μM (86.2%), a result in good agreement with the observed strong hydroxyl radical scavenger of QN6.

Keywords: Antioxidants; cerebral ischemia; free radical scavengers; neuroprotection; quinolylnitrones; synthesis.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Humans
  • Neurons / drug effects*
  • Neuroprotective Agents / pharmacology*
  • Nitrogen Oxides / pharmacology
  • Quinolines / pharmacology


  • Antioxidants
  • Neuroprotective Agents
  • Nitrogen Oxides
  • Quinolines
  • nitrones