Validation of a physician global assessment tool for vitiligo extent: Results of an international vitiligo expert meeting

Nanja van Geel; Albert Wolkerstorfer; Khaled Ezzedine; Amit G Pandya; Marcel Bekkenk; Lynda Grine; Sarah Van Belle; Janny E Lommerts; Iltefat Hamzavi; John E Harris; Viktoria Eleftheriadou; Samia Esmat; Hee Young Kang; Prasad Kumarasinghe; Cheng-Che E Lan; Davinder Parsad; Noufal Raboobee; Leihong Flora Xiang; Tamio Suzuki; Cecilia A Prinsen; Alain Taieb; Mauro Picardo; Reinhart Speeckaert; participants of the Rome International VGICC /VIS Workshop

doi:10.1111/pcmr.12784

Validation of a physician global assessment tool for vitiligo extent: Results of an international vitiligo expert meeting

Pigment Cell Melanoma Res. 2019 Sep;32(5):728-733. doi: 10.1111/pcmr.12784. Epub 2019 May 9.

Authors

Nanja van Geel¹, Albert Wolkerstorfer², Khaled Ezzedine³, Amit G Pandya⁴, Marcel Bekkenk², Lynda Grine¹, Sarah Van Belle¹, Janny E Lommerts², Iltefat Hamzavi⁵, John E Harris⁶, Viktoria Eleftheriadou⁷, Samia Esmat⁸, Hee Young Kang⁹, Prasad Kumarasinghe¹⁰, Cheng-Che E Lan¹¹, Davinder Parsad¹², Noufal Raboobee¹³, Leihong Flora Xiang¹⁴, Tamio Suzuki¹⁵, Cecilia A Prinsen¹⁶, Alain Taieb¹⁷, Mauro Picardo¹⁸, Reinhart Speeckaert¹; participants of the Rome International VGICC /VIS Workshop

Collaborators

participants of the Rome International VGICC /VIS Workshop:
Tag Anbar, Mohamed Anbar, Laïla Benzekri, Markus Böhm, Caïo Castro, Tania Cestari, Yvon Gauthier, Maria Gnarra, Jorge Hinojosa, Min Bae Jung, Ichiro Katayama, Ki-Ho Kim, Cheng-Che Eric Lan, Seung-Chung Lee, Caroline Le Poole, Henry Lim, Silvia Moretti, Julien Seneschal, Richard Spritz, Nanja van Geel, Flora Xiang

Affiliations

¹ Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
² Department of Dermatology, Institute for Pigment Disorders and Infection, Immunity Institute Amsterdam UMC, Amsterdam, The Netherlands.
³ Department of Dermatology, Henri Mondor Hospital, UPE-Université Paris-Est, Créteil, France.
⁴ Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
⁵ Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
⁶ Department of Dermatology, The University of Massachusetts Medical School, Worcester, Massachusetts.
⁷ Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.
⁸ Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
⁹ Department of dermatology, Ajou University School of Medicine, Suwon, Korea.
¹⁰ Department of Dermatology, Fiona Stanley Hospital, University of Western Australia, Perth, Western Australia, Australia.
¹¹ Department of Dermatology, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
¹² Department of Dermatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
¹³ Department of Dermatology, Westville Hospital, Westville, South Africa.
¹⁴ Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
¹⁵ Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
¹⁶ Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, The Netherlands.
¹⁷ Department of Dermatology, INSERM U 1035, Bordeaux University Hospitals, University of Bordeaux, Bordeaux, France.
¹⁸ San Gallicano Dermatologic Institute, Rome, Italy.

PMID: 30945409
DOI: 10.1111/pcmr.12784

Abstract

Currently, vitiligo lacks a validated Physician Global Assessment (PGA) for disease extent. This PGA can be used to stratify and interpret the numeric scores obtained by the Vitiligo Extent Score (VES). We investigated the interrater reliability of a 5-point PGA scale during an international vitiligo workshop. Vitiligo experts from five different continents rated photographs of non-segmental vitiligo patients with varying degrees of extent with the PGA score. Good interrater agreements (intraclass correlation coefficient >0.6) were observed between the raters overall and within each continent. All hypotheses to evaluate construct validity were confirmed. Median VES values per category were for limited 1.10 [IQR: 0.21-1.67], moderate 3.17 [IQR: 1.75-6.21], extensive 9.58 [IQR: 6.21-13.03] and very extensive 42.67 [IQR: 21.20-42.67]. Defined categories for vitiligo extent can be valuable for inclusion criteria and may impact future reimbursement criteria.

Keywords: body surface area; extent; global assessment; outcome measure; severity; vitiligo.

Publication types

Research Support, Non-U.S. Gov't
Validation Study

MeSH terms

Dermatologists / standards*
Diagnostic Tests, Routine / standards*
Global Health*
Humans
Internationality
Observer Variation
Reproducibility of Results
Risk Assessment / standards*
Severity of Illness Index*
Vitiligo / diagnosis*