Hepatic Complications of Inflammatory Bowel Disease

Clin Liver Dis. 2019 May;23(2):191-208. doi: 10.1016/j.cld.2018.12.003. Epub 2019 Feb 26.


Hepatobiliary disorders are commonly encountered in patients with inflammatory bowel disease (IBD). Although primary sclerosing cholangitis is the stereotypical hepatobiliary disorder associated with IBD, other diseases, including autoimmune hepatitis and nonalcoholic fatty liver disease, also are encountered in this population. Several agents used for treatment of IBD may cause drug-induced liver injury, although severe hepatotoxicity occurs infrequently. Furthermore, reactivation of hepatitis B virus infection may occur in patients with IBD treated with systemic corticosteroids and biologic agents.

Keywords: Autoimmune hepatitis; Drug-induced liver injury; Hepatitis B reactivation; Hepatobiliary disorders; Inflammatory bowel disease; Nonalcoholic fatty liver disease; Primary sclerosing cholangitis.

Publication types

  • Review

MeSH terms

  • Bile Duct Neoplasms / epidemiology
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cholangiocarcinoma / epidemiology
  • Cholangitis, Sclerosing / diagnosis
  • Cholangitis, Sclerosing / etiology*
  • Cholangitis, Sclerosing / therapy
  • Hepatitis, Autoimmune / etiology
  • Hepatitis, Viral, Human / epidemiology
  • Humans
  • Inflammatory Bowel Diseases / complications*
  • Inflammatory Bowel Diseases / drug therapy
  • Liver Diseases / epidemiology*
  • Liver Diseases / etiology*