Rat models of colistin nephrotoxicity: previous experimental researches and future perspectives

Eur J Clin Microbiol Infect Dis. 2019 Aug;38(8):1387-1393. doi: 10.1007/s10096-019-03546-7. Epub 2019 Apr 4.

Abstract

Colistin is an old antibiotic, which is abandoned decades ago because of high nephrotoxicity rates. However, it is reintroduced to clinical medicine due to lack of newly discovered antibiotics and is still widely used for the treatment of resistant gram-negative infections. Discovering mechanisms to reduce nephrotoxicity risk is of significant importance since exposed patients may have many other factors that alter kidney functions. Several agents were evaluated in animal models of colistin nephrotoxicity as a means to prevent kidney injury. Considerable heterogeneity exists in terms of reporting colistin dosing and experimental designs. This issue leads clinicians to face difficulties in designing studies and sometimes may lead to report dosing strategies inadequately. Here, we present a review according to animal models of colistin nephrotoxicity using data gathered from previous experiments to draw attention on possible complexities that researchers may encounter.

Keywords: Animal model; Colistin; Nephrotoxicity.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / prevention & control
  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / toxicity*
  • Colistin / administration & dosage
  • Colistin / toxicity*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Kidney / drug effects*
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Risk Factors
  • Toxicity Tests

Substances

  • Anti-Bacterial Agents
  • Colistin