Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage

Eur J Immunol. 1986 Oct;16(10):1313-6. doi: 10.1002/eji.1830161021.


Previous reconstitution studies in irradiated mice distinguished Ly-1 B from other B cells. The predominant B cell populations in spleen and lymph node are readily reconstituted from progenitors present in adult bone marrow. Ly-1 B cells, in contrast, are reconstituted from cells in peritoneum rather than bone marrow. Further studies, presented here, demonstrate that Ly-1 B populations are reconstituted from peritoneal cells that already express both surface immunoglobulin (IgM) and Ly-1, that is, Ly-1 B. Such cells reconstitute and maintain the Ly-1 B population in irradiated recipients for at least 6 months.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Ly / analysis*
  • B-Lymphocytes / immunology*
  • Cell Separation
  • Flow Cytometry
  • Hematopoietic Stem Cells / immunology
  • Immunoglobulin Light Chains / analysis
  • Immunoglobulins / analysis*
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred CBA
  • Peritoneal Cavity / cytology
  • Spleen / cytology


  • Antigens, Ly
  • Immunoglobulin Light Chains
  • Immunoglobulins