Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders

doi:10.1136/jnnp-2018-320287

. 2019 Nov;90(11):1293-1296.

doi: 10.1136/jnnp-2018-320287. Epub 2019 Apr 5.

Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders

Sara Mariotto¹, Sergio Ferrari², Matteo Gastaldi³, Diego Franciotta³, Elia Sechi⁴, Ruggero Capra⁵, Chiara Mancinelli⁵, Kathrin Schanda⁶, Daniela Alberti², Riccardo Orlandi², Roberto Bombardi⁷, Luigi Zuliani⁸, Marco Zoccarato⁹, Maria Donata Benedetti², Raffaella Tanel¹⁰, Francesca Calabria¹¹, Francesca Rossi¹², Antonino Pavone¹³, Luisa Grazian¹⁴, GianPietro Sechi¹⁵, Lucia Batzu⁴, Noemi Murdeu⁴, Francesco Janes¹⁶, Vincenza Fetoni¹⁷, Daniela Fulitano¹⁸, Gianola Stenta¹⁹, Lisa Federle¹⁹, Gaetano Cantalupo²⁰, Markus Reindl⁶, Salvatore Monaco², Alberto Gajofatto²

Affiliations

¹ Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy sara.mariotto@gmail.com.
² Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy.
³ Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy, Pavia, Italy.
⁴ Department of Clinical and Experimental Medicine, Neurology Unit, University of Sassari, Sassari, Italy.
⁵ MS Center, Spedali Civili of Brescia, Brescia, Italy.
⁶ Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
⁷ Neurology Unit, San Bassiano Hospital, Bassano Del Grappa, Italy.
⁸ Department of Neurology, Ospedale Ca' Foncello, Treviso, Italy.
⁹ O.S.A, Padova, Italy, Neurology Unit, Padova, Italy.
¹⁰ U.O. Neurologia, S. Chiara Hospital, Trento, Italy.
¹¹ AOUI Verona, Neurology Unit, Verona, Italy.
¹² Neurology Unit, Mater Salutis Hospital, Legnago, Verona, Italy, Verona, Italy.
¹³ Neurology Unit, Garibaldi Hospital, Catania, Italy, Catania, Italy.
¹⁴ Pediatric Unit, ULSS 2 Marca Trevigiana, Ca' Foncello Hospital, Treviso, Italy, Treviso, Italy.
¹⁵ Department of Clinical and Experimental Medicine, NeurologyUnit, University of Sassari, Sassari, Italy.
¹⁶ Neurology Unit, Department of Neuroscience ASUIUD, Udine, Italy, Udine, Italy.
¹⁷ Neurology Department, ASST Fatebenefratelli Sacco, Milano, Italy, Milano, Italy.
¹⁸ Neurology Unit, Rovigo, Italy, Rovigo, Italy.
¹⁹ Multiple Sclerosis Centre, S. Bortolo Hospital, Vicenza, Italy, Vicenza, Italy.
²⁰ Child Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

PMID: 30952681
DOI: 10.1136/jnnp-2018-320287

Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders

Sara Mariotto et al. J Neurol Neurosurg Psychiatry. 2019 Nov.

. 2019 Nov;90(11):1293-1296.

doi: 10.1136/jnnp-2018-320287. Epub 2019 Apr 5.

Authors

Affiliations

¹ Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy sara.mariotto@gmail.com.
² Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy.
³ Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy, Pavia, Italy.
⁴ Department of Clinical and Experimental Medicine, Neurology Unit, University of Sassari, Sassari, Italy.
⁵ MS Center, Spedali Civili of Brescia, Brescia, Italy.
⁶ Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
⁷ Neurology Unit, San Bassiano Hospital, Bassano Del Grappa, Italy.
⁸ Department of Neurology, Ospedale Ca' Foncello, Treviso, Italy.
⁹ O.S.A, Padova, Italy, Neurology Unit, Padova, Italy.
¹⁰ U.O. Neurologia, S. Chiara Hospital, Trento, Italy.
¹¹ AOUI Verona, Neurology Unit, Verona, Italy.
¹² Neurology Unit, Mater Salutis Hospital, Legnago, Verona, Italy, Verona, Italy.
¹³ Neurology Unit, Garibaldi Hospital, Catania, Italy, Catania, Italy.
¹⁴ Pediatric Unit, ULSS 2 Marca Trevigiana, Ca' Foncello Hospital, Treviso, Italy, Treviso, Italy.
¹⁵ Department of Clinical and Experimental Medicine, NeurologyUnit, University of Sassari, Sassari, Italy.
¹⁶ Neurology Unit, Department of Neuroscience ASUIUD, Udine, Italy, Udine, Italy.
¹⁷ Neurology Department, ASST Fatebenefratelli Sacco, Milano, Italy, Milano, Italy.
¹⁸ Neurology Unit, Rovigo, Italy, Rovigo, Italy.
¹⁹ Multiple Sclerosis Centre, S. Bortolo Hospital, Vicenza, Italy, Vicenza, Italy.
²⁰ Child Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

PMID: 30952681
DOI: 10.1136/jnnp-2018-320287

No abstract available

Keywords: MOG; NMOSD; myelitis; neurofilament light chain; optic neuritis.

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Conflict of interest statement

Competing interests: SMA was sponsored by Merck and Euroimmun for attending scientific meeting. SF was sponsored by Shire and Euroimmun for attending scientific meeting. RC received lecture fees and/or travel grants from Novartis, Biogen, Celgene, Novartis, TEVA, Genzyme and Sanofi-Aventis. MR was supported by a research grant from the Austrian Science Promotion Agency (FFG). The University Hospital and Medical University of Innsbruck (Austria; MR) receives payments for antibody assays (MOG, AQP4, and other autoantibodies) and for MOG and AQP4 antibody validation experiments organised by Euroimmun (Lübeck, Germany). SMO received honoraria from Biogen. AG received research support funding from Merck.

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Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders

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Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders

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Conflict of interest statement

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