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. 2019 May;39(2):163-175.
doi: 10.1016/j.iac.2018.12.005.

The Effects of the Environment on Asthma Disease Activity

Free PMC article

The Effects of the Environment on Asthma Disease Activity

Margee Louisias et al. Immunol Allergy Clin North Am. .
Free PMC article


Asthma is highly prevalent and causes significant morbidity in children. The development of asthma depends on complex relationships between genetic predisposition and environmental modifiers of immune function. The biological and physical environmental factors include aeroallergens, microbiome, endotoxin, genetics, and pollutants. The psychosocial environment encompasses stress, neighborhood safety, housing, and discrimination. They all have been speculated to influence asthma control and the risk of developing asthma. Control of the factors that contribute to or aggravate symptoms, interventions to eliminate allergen exposure, guidelines-based pharmacologic therapy, and education of children and their caregivers are of paramount importance.

Keywords: Allergens; Asthma; Asthma morbidity; Disparities; Endotoxin; Environment; Microbiome; Pollutants.

Conflict of interest statement

Summary conflict of interest statements for each author (or a statement indicating no conflicts exist for the specified author[s]): All authors have no conflicts of interest.

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