Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease

Clin Biochem. 2019 Oct:72:87-89. doi: 10.1016/j.clinbiochem.2019.04.001. Epub 2019 Apr 4.


Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and dementia. The pathological characteristics of AD include the deposition of amyloid beta (Aβ), neurofibrillary tangles, and neuronal loss. There is evidence showing the involvement of inflammation in AD, including activated microglia within and surrounding senile plaques. Epidemiological studies suggest the use of anti-inflammatory drugs to reduce incidence of AD. However, clinical trials with anti-inflammatory drugs have not been successful.

Keywords: Alzheimer's disease; Inflammation; NSAIDs; Treatment.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / complications
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / physiopathology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Humans
  • Inflammation / complications
  • Inflammation / drug therapy*


  • Anti-Inflammatory Agents, Non-Steroidal