Treatment of primary hyperhidrosis

Mayo Clin Proc. 1986 Dec;61(12):951-6. doi: 10.1016/s0025-6196(12)62635-4.


Primary hyperhidrosis is a physically and emotionally distressing condition. Physicians should be aware of the various treatment modalities available for controlling or reducing the profuse sweating, which involves mainly the palms, soles, and axillas. The simplest methods, such as topical application of aluminum chloride, should be attempted first. If topical medications are ineffective, iontophoresis may provide relief, especially in patients with plantar or palmar involvement. When patients are unresponsive to other treatment options, surgical intervention may be warranted-excision of sweat glands in patients with axillary hyperhidrosis and upper thoracic sympathectomy in those with palmar involvement. Although excellent results have been reported, complications and resumption of sweating have occurred.

MeSH terms

  • Administration, Topical
  • Aluminum / administration & dosage
  • Aluminum Chloride
  • Aluminum Compounds*
  • Axilla
  • Chlorides*
  • Female
  • Glutaral / administration & dosage
  • Humans
  • Hyperhidrosis / therapy*
  • Iontophoresis
  • Male
  • Parasympatholytics / therapeutic use
  • Recurrence
  • Sweat Glands / surgery
  • Sympathectomy


  • Aluminum Compounds
  • Chlorides
  • Parasympatholytics
  • Aluminum Chloride
  • Aluminum
  • Glutaral