Human BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy

Rodrigo Jiménez-Saiz; Yosef Ellenbogen; Kelly Bruton; Paul Spill; Doron D Sommer; Hermenio Lima; Susan Waserman; Sarita U Patil; Wayne G Shreffler; Manel Jordana

doi:10.1016/j.jaci.2019.04.001

Human BCR analysis of single-sorted, putative IgE⁺ memory B cells in food allergy

J Allergy Clin Immunol. 2019 Jul;144(1):336-339.e6. doi: 10.1016/j.jaci.2019.04.001. Epub 2019 Apr 5.

Authors

Affiliations

¹ McMaster Immunology Research Centre (MIRC), Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.
² McMaster Immunology Research Centre (MIRC), Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
³ Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
⁴ Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
⁵ Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.
⁶ McMaster Immunology Research Centre (MIRC), Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address: jordanam@mcmaster.ca.

Abstract

R. Jimenez-Saiz, Y. Ellenbogen and K. Bruton et al. developed a method to identify bona fide IgE⁺ MBCs in humans, demonstrated their extreme rarity in circulation and cautioned against the clinical utility of their assessment.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
B-Lymphocytes / immunology*
Cells, Cultured
Child
Child, Preschool
Female
Food Hypersensitivity / blood
Food Hypersensitivity / immunology*
Humans
Immunoglobulin E / blood
Immunoglobulin E / immunology*
Male
Middle Aged
Palatine Tonsil / immunology
Receptors, Antigen, B-Cell / immunology*
Young Adult

Substances

Receptors, Antigen, B-Cell
Immunoglobulin E

Grants and funding

K23 AI121491/AI/NIAID NIH HHS/United States