Implications of fatherhood in cystic fibrosis

Paediatr Respir Rev. 2019 Aug;31:18-20. doi: 10.1016/j.prrv.2019.02.008. Epub 2019 Mar 16.

Abstract

Advances in fertility treatment mean that men with CF are increasingly able to become fathers. Here we report clinical outcomes in 22 men with CF who have become fathers for the first time. Overall mean (SD) FEV1% predicted declined from 60.1(18.0)% to 57.4(20.2)% from baseline to 1 year (p = 0.15). Weight declined from mean (SD) 70.6 kg (10.4) to 68.3 kg (10.2), p = 0.0001. Six men had an FEV1% predicted ≤40% at the time of birth: 50% died or received lung transplantation within the 12-15 month follow up period. Becoming a parent is a major life event, and as with new mothers, fathers with CF may be at risk of significant decline.

Keywords: Clinical decline; Cystic fibrosis; Fatherhood; Lung function; Weight.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / mortality
  • Cystic Fibrosis / physiopathology*
  • Cystic Fibrosis / surgery
  • Diabetes Mellitus
  • Disease Progression
  • Exocrine Pancreatic Insufficiency
  • Fathers*
  • Forced Expiratory Volume
  • Humans
  • Infertility, Male / etiology
  • Infertility, Male / therapy*
  • Longitudinal Studies
  • Lung Transplantation
  • Male
  • Mortality
  • Reproductive Techniques, Assisted
  • Retrospective Studies

Substances

  • Anti-Bacterial Agents