This report details the naturopathic treatment of a 28-y-old female with a 1 y history of abdominal pain, heartburn, and constipation as well as longstanding anxiety and depression. Clinical evaluation ruled out organic causes of dyspepsia such as peptic ulcer disease, Helicobacter pylori infection, and nonsteroidal anti-inflammatory drugs-induced dyspepsia. Treatment consisting of soft-tissue manipulation, homeopathic prescription, nutritional supplementation, and lifestyle modification greatly improved gastrointestinal and mental-emotional symptoms after 2 wk. Improvement in anxiety and depression was substantiated with Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 questionnaires.