Treatment of Radiation-Induced Cognitive Decline in Adult Brain Tumor Patients

Curr Treat Options Oncol. 2019 Apr 8;20(5):42. doi: 10.1007/s11864-019-0641-6.


Patients with either primary or metastatic brain tumors quite often have cognitive impairment. Maintaining cognitive function is important to brain tumor patients and a decline in cognitive function is generally accompanied by a decline in functional independence and performance status. Cognitive decline can be a result of tumor progression, depression/anxiety, fatigue/sleep dysfunction, or the treatments they have received. It is our opinion that providers treating brain tumor patients should obtain pre-treatment and serial cognitive testing in their patients and offer mitigating and therapeutic interventions when appropriate. They should also support cognition-focused clinical trials.

Keywords: Attention; Brain; Cognition; Memory; Neuropsychology; Radiation.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / complications*
  • Brain Neoplasms / radiotherapy
  • Cognitive Dysfunction / diagnosis
  • Cognitive Dysfunction / etiology*
  • Cognitive Dysfunction / prevention & control
  • Cognitive Dysfunction / therapy*
  • Disease Susceptibility
  • Humans
  • Neuropsychological Tests
  • Quality of Life
  • Radiotherapy / adverse effects*
  • Radiotherapy / methods
  • Symptom Assessment
  • Treatment Outcome