Anti-obesity potential of rare sugar d-psicose by regulating lipid metabolism in rats

Food Funct. 2019 May 22;10(5):2417-2425. doi: 10.1039/c8fo01089g.


d-Psicose is a new-generation sugar substitute with a low calorie count and can still offer the desirable sweetness. The objective of this study was to investigate the antiobesity potential of d-psicose and the possible mechanism using Wistar rats as the animal model. The animals were divided into five groups and supplemented with diets containing 5% of different carbohydrates, such as glucose, fructose, cellulose, d-psicose, and a control diet, for 4 weeks. After sacrifice, blood lipid profile, tissue morphology, and related genes participating in lipid metabolism were analyzed. The results indicated that the supplementation by d-psicose leads to minimum fat accumulation in rats when compared with the other carbohydrates. The blood lipid profile and antioxidative activity of the rat were also improved. d-Psicose can regulate lipid metabolism by increasing the lipid-metabolism-related enzymes such as SDH in serum and liver and HL in the liver. d-Psicose can prevent fat accumulation by suppressing the expression of lipogenesis-related gene ACCα and hepatic fatty acid uptake gene (FAS and SREBP-1c), while stimulating the expression for fatty-acid-oxidation-related gene including AMPK2α, HSL, and PPARα. In conclusion, d-psicose can be considered to be a healthy alternative to traditional sweeteners.

MeSH terms

  • Animals
  • Anti-Obesity Agents / metabolism*
  • Fructose / metabolism*
  • Glucose / metabolism
  • Humans
  • Insulin / metabolism
  • Lipid Metabolism*
  • Lipids / blood
  • Male
  • Obesity / diet therapy*
  • Obesity / genetics
  • Obesity / metabolism
  • PPAR alpha / genetics
  • PPAR alpha / metabolism
  • Rats
  • Rats, Wistar
  • Sterol Regulatory Element Binding Protein 1 / genetics
  • Sterol Regulatory Element Binding Protein 1 / metabolism
  • fas Receptor / genetics
  • fas Receptor / metabolism


  • Anti-Obesity Agents
  • Fas protein, rat
  • Insulin
  • Lipids
  • PPAR alpha
  • Sterol Regulatory Element Binding Protein 1
  • fas Receptor
  • psicose
  • Fructose
  • Glucose