Ontogeny of spontaneous petit mal-like seizures in Wistar rats

Brain Res. 1986 Nov;395(1):85-7. doi: 10.1016/s0006-8993(86)80011-7.

Abstract

Wistar rats spontaneously presenting electroclinical signs of petit mal-like epileptic seizures were inbred until all offspring were affected, and the ontogeny of this inherited phenotype was studied in the offspring from 30-60 days of age to 18 months. The first EEG spike and wave discharges appeared at 40-120 days. Their number and duration increased progressively with age.

MeSH terms

  • Aging / physiology*
  • Animals
  • Disease Models, Animal
  • Electroencephalography
  • Epilepsy, Absence / genetics
  • Epilepsy, Absence / physiopathology*
  • Female
  • Male
  • Rats
  • Rats, Inbred Strains