New Dammarane-type Saponins from Gynostemma pentaphyllum

Molecules. 2019 Apr 8;24(7):1375. doi: 10.3390/molecules24071375.

Abstract

Six new dammarane-type saponins, gypenosides CP1-6 (16), along with 19 known compounds 725, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).

Keywords: Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Proliferation / drug effects
  • Gynostemma / chemistry*
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Plant Components, Aerial / chemistry
  • Plant Extracts / chemistry
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Triterpenes

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Saponins
  • Triterpenes
  • dammarane