Surface Modification of Cardiovascular Stent Material 316L SS with Estradiol-Loaded Poly (trimethylene carbonate) Film for Better Biocompatibility

Hang Yao; Jingan Li; Na Li; Kebing Wang; Xin Li; Jin Wang

doi:10.3390/polym9110598

Surface Modification of Cardiovascular Stent Material 316L SS with Estradiol-Loaded Poly (trimethylene carbonate) Film for Better Biocompatibility

Polymers (Basel). 2017 Nov 10;9(11):598. doi: 10.3390/polym9110598.

Authors

Hang Yao¹, Jingan Li^{2

3}, Na Li⁴, Kebing Wang⁵, Xin Li⁶, Jin Wang⁷

Affiliations

¹ Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. yaohang1990@my.swjtu.edu.cn.
² Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. lijingan@zzu.edu.cn.
³ School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450000, China. lijingan@zzu.edu.cn.
⁴ Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. ln1432728994@my.swjtu.edu.cn.
⁵ Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. 2016310129@my.swjtu.edu.cn.
⁶ Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. lixin131715@home.swjtu.edu.cn.
⁷ Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. wangjin@home.swjtu.edu.cn.

Abstract

A delay in the endothelialization process represents a bottleneck in the application of a drug-eluting stent (DES) during cardiovascular interventional therapy, which may lead to a high risk of late restenosis. In this study, we used a novel active drug, estradiol, which may contribute to surface endothelialization of a DES, and prepared an estradiol-loaded poly (trimethylene carbonate) film (PTMC-E5) on the surface of the DES material, 316L stainless steel (316L SS), in order to evaluate its function in improving surface endothelialization. All the in vitro and in vivo experiments indicated that the PTMC-E5 film significantly improved surface hemocompatibility and anti-hyperplasia, anti-inflammation and pro-endothelialization properties. This novel drug-delivery system may provide a breakthrough for the surface endothelialization of cardiovascular DES.

Keywords: PTMC; biocompatibility; cardiovascular stent; estradiol; surface modification.

Abstract

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