Improved in vitro fertilization success and pregnancy outcome with autologous platelet-rich plasma treatment in unexplained infertility patients that had repeated implantation failure history

Gynecol Endocrinol. 2019 Sep;35(9):815-818. doi: 10.1080/09513590.2019.1597344. Epub 2019 Apr 10.


Repeated implantation failure (RIF) due to suboptimal endometrial lining is a major challenge in reproductive medicine. The study aims to evaluate effect of intrauterine platelet-rich plasma (PRP) treatment on frozen-thawed embryo transfer (FET) cycles in patients whose endometrium was unable to achieve optimal lining in unexplained infertility patients with history of RIF. We retrospectively analyzed the charts of a total of 302 cycles performed in 273 patients attending Diyar Life ART Centre between January 2014 and January 2017. After excluding 232 cycles, we compared pregnancy outcomes of 34 patients who had suboptimal endometrial lining and underwent PRP + FET and 36 patients who had optimal endometrial lining and underwent only FET. We observed that, endometrial thickness was higher after 48 hours from PRP when compared to endometrial thickness before PRP (10 mm vs. 6.25 mm, p < .001). Clinical pregnancy rate, and importantly live birth rate were also significantly higher in PRP group than the control group. Based on this information, we showed that intrauterine autologous PRP infusion is a safe, inexpensive adjuvant treatment for optimizing endometrium especially in patients with RIF history and intrauterine PRP infusion improved not only endometrial lining but also in vitro fertilization success and pregnancy outcome.

Keywords: fertilization; live birth rate; platelet rich plasma; pregnancy outcome; repeated implantation failure; suboptimal endometrium.

MeSH terms

  • Abortion, Habitual / etiology
  • Abortion, Habitual / physiopathology
  • Abortion, Habitual / therapy*
  • Adult
  • Blood Component Transfusion* / methods
  • Embryo Implantation / physiology*
  • Estradiol / therapeutic use
  • Female
  • Fertilization in Vitro / methods*
  • Hormone Replacement Therapy
  • Humans
  • Infertility, Female / etiology
  • Infertility, Female / physiopathology
  • Infertility, Female / therapy*
  • Platelet-Rich Plasma / physiology*
  • Pregnancy
  • Pregnancy Outcome
  • Reproductive History
  • Retrospective Studies
  • Transplantation, Autologous
  • Treatment Outcome
  • Young Adult


  • Estradiol