The Drosophila virilis dopa decarboxylase gene is developmentally regulated when integrated into Drosophila melanogaster

EMBO J. 1986 Sep;5(9):2305-11.


The dopa decarboxylase gene (Ddc) has been isolated from Drosophila virilis and introduced into the germ-line of Drosophila melanogaster by P-element mediated transformation. The integrated gene is induced at the correct stages during development with apparently normal tissue specificity, indicating that cis-acting elements required for regulation are functionally conserved between the two species. A comparison of the DNA sequences from the 5' flanking regions reveals a cluster of small (8-16 bp) conserved sequence elements within 150 bp upstream of the RNA startpoint, a region required for normal expression of the D. melanogaster Ddc gene.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aromatic-L-Amino-Acid Decarboxylases / genetics*
  • Base Sequence
  • DNA / ultrastructure
  • Dopa Decarboxylase / genetics*
  • Drosophila / enzymology
  • Drosophila / genetics*
  • Drosophila / growth & development
  • Drosophila melanogaster / genetics*
  • Genes*
  • Genes, Regulator*
  • Species Specificity
  • Transformation, Genetic*


  • DNA
  • Dopa Decarboxylase
  • Aromatic-L-Amino-Acid Decarboxylases

Associated data

  • GENBANK/X04661
  • GENBANK/X05065