Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination

Jerilyn R Izac; Richard T Marconi

doi:10.1016/j.cvsm.2019.02.007

Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination

Vet Clin North Am Small Anim Pract. 2019 Jul;49(4):671-686. doi: 10.1016/j.cvsm.2019.02.007. Epub 2019 Apr 6.

Authors

Jerilyn R Izac¹, Richard T Marconi²

Affiliations

¹ Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University Medical Center, 1112 East Clay Street, Room 101 McGuire Hall, PO Box 980678, Richmond, VA 23298-0678, USA.
² Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University Medical Center, 1112 East Clay Street, Room 101 McGuire Hall, PO Box 980678, Richmond, VA 23298-0678, USA. Electronic address: richard.marconi@vcuhealth.org.

Abstract

The Lyme disease spirochetes are a highly diverse group of bacteria with unique biological properties. Their ability to cycle between ticks and mammals requires that they adapt to variable and constantly changing environmental conditions. Outer surface protein C is an essential virulence determinant that has received considerable attention in vaccine and diagnostic assay development. Knowledge of OspC diversity, its antigenic determinants, and its production patterns throughout the enzootic cycle, as well as in the laboratory setting, is essential for understanding immune responses induced by infection or vaccination.

Keywords: Borrelia; Canines; Ixodes ticks; Lyme diagnostics; Lyme disease; Lyme vaccines; OspA; OspC.

Publication types

Review

MeSH terms

Animals
Bacterial Vaccines / immunology*
Borrelia burgdorferi / genetics*
Lyme Disease / immunology
Lyme Disease / microbiology
Lyme Disease / prevention & control
Lyme Disease / veterinary*
Pets*

Substances

Bacterial Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding