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Review
. 2019 Mar 22;7:76.
doi: 10.3389/fped.2019.00076. eCollection 2019.

Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification

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Review

Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification

Sertac Arslanoglu et al. Front Pediatr. .
Free PMC article

Abstract

Evidence indicates that human milk (HM) is the best form of nutrition uniquely suited not only to term but also to preterm infants conferring health benefits in both the short and long-term. However, HM does not provide sufficient nutrition for the very low birth weight (VLBW) infant when fed at the usual feeding volumes leading to slow growth with the risk of neurocognitive impairment and other poor health outcomes such as retinopathy and bronchopulmonary dysplasia. HM should be supplemented (fortified) with the nutrients in short supply, particularly with protein, calcium, and phosphate to meet the high requirements of this group of babies. In this paper the European Milk Bank Association (EMBA) Working Group on HM Fortification discusses the existing evidence in this field, gives an overview of different fortification approaches and definitions, outlines the gaps in knowledge and gives recommendations for practice and suggestions for future research. EMBA recognizes that "Standard Fortification," which is currently the most utilized regimen in neonatal intensive care units, still falls short in supplying sufficient protein for some VLBW infants. EMBA encourages the use of "Individualized Fortification" to optimize nutrient intake. "Adjustable Fortification" and "Targeted Fortification" are 2 methods of individualized fortification. The quality and source of human milk fortifiers constitute another important topic. There is work looking at human milk derived fortifiers, but it is still too early to draw precise conclusions about their use. The pros and cons are discussed in this Commentary in addition to the evidence around use of fortifiers post discharge.

Keywords: adjustable fortification; growth; human milk; individualized fortification; nutrition; prematurity; protein.

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References

    1. Stephens BE, Vohr BR. Protein intake and neurodevelopmental outcomes. Clin Perinatol. (2014) 41:323–29. 10.1016/j.clp.2014.02.005 - DOI - PubMed
    1. Belfort MB, Ehrenkranz RA. Neurodevelopmental outcomes and nutritional strategies in very low birth weight infants. Semin Fetal Neonatal Med. (2017) 22:42–8. 10.1016/j.siny.2016.09.001 - DOI - PubMed
    1. Lucas A, Morley R, Cole T. Randomised trial of early diet in preterm babies and later intelligence quotient. BMJ. (1998) 317:1481–7. 10.1136/bmj.317.7171.1481 - DOI - PMC - PubMed
    1. Latal-Hajnal B, von Siebenthal K, Kovari H, Bucher HU, Largo RH. Postnatal growth in VLBW infants: significant association with neurodevelopmental outcome. J Pediatr. (2003) 143:163–70. 10.1067/S0022-3476(03)00243-9 - DOI - PubMed
    1. Ehrenkranz RA, Dusick AM, Vohr BR, Wright LL, Wrage LA, Poole WK. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics. (2006) 117:1253–61. 10.1542/peds.2005-1368 - DOI - PubMed
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