Aerobic exercise and Orexin A: role of sympathetic activity and redox system

J Biol Regul Homeost Agents. 2019;33(2):587-592.


Aerobic exercise is associated with the sympathetic activation evoking adaptive responses to sustain muscle engagement. Physical exercise can cause alterations in the cardiovascular activity and cellular stress may occur which could be marked by either heart rate (HR), or galvanic skin response (GSR). Moderate plasma levels of reactive oxygen species (ROS) are considered as health markers, absolving to important roles such as adaptive cellular responses to exercise. Orexin A, a hypothalamic peptide, causes a widespread stimulation of the sympathetic nervous system, playing a role in many physiological functions.

Keywords: UCPs; exercise; orexin A; reactive oxygen species; sympathetic activity.

Publication types

  • Letter

MeSH terms

  • Exercise*
  • Heart Rate
  • Humans
  • Orexins / physiology*
  • Oxidation-Reduction
  • Reactive Oxygen Species / metabolism
  • Sympathetic Nervous System / physiology*


  • Orexins
  • Reactive Oxygen Species