The role of vasodilator-stimulated phosphoprotein in podocyte functioning

Cell Biol Int. 2019 Oct;43(10):1092-1101. doi: 10.1002/cbin.11149. Epub 2019 Jul 22.

Abstract

Vasodilator-stimulated phosphoprotein (VASP) is a 39-kDa protein belonging to the Ena/VASP protein family, which is involved in adhesion, migration, cell-cell interaction, and regulation of pathways connected with actin cytoskeleton remodeling. VASP is phosphorylated at Tyr39, Ser157, Ser239, Thr278, and Ser322 mainly by tyrosine kinase Abl, cAMP-dependent protein kinase, protein kinase G, AMP-activated protein kinase, and protein kinase D1, respectively. VASP phosphorylation, as a regulator of actin dynamics, may lead to impaired reorganization of the podocyte actin cytoskeleton not only by indirect interaction of VASP with actin but also by regulation of other signaling pathways. A few studies have shown that VASP participates in the development of renal diseases and mediates podocyte movement through its interaction with proteins of the slit diaphragm. VASP phosphorylation may cause reduced actin filament assembly in podocytes and mediate disturbances in regulation of filtration barrier permeability as a consequence of podocyte foot process effacement. In this paper, we describe the role of VASP in podocyte function, mainly in the context of actin dynamics and glomerular filtration barrier permeability. In addition, we discuss the involvement of VASP and its phosphorylated forms in the development of kidney diseases.

Keywords: actin cytoskeleton; filtration barrier permeability; podocyte; slit diaphragm; vasodilator-stimulated phosphoprotein.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Actins / metabolism
  • Animals
  • Cell Adhesion Molecules / physiology*
  • Humans
  • Kidney Diseases / metabolism*
  • Mice
  • Microfilament Proteins / physiology*
  • Phosphoproteins / physiology*
  • Phosphorylation
  • Podocytes / cytology
  • Podocytes / metabolism*
  • Podocytes / pathology
  • Rats

Substances

  • Actins
  • Cell Adhesion Molecules
  • Microfilament Proteins
  • Phosphoproteins
  • vasodilator-stimulated phosphoprotein