Prognostic factors in metastatic germ-cell cancer

Andrology. 2019 Jul;7(4):475-478. doi: 10.1111/andr.12615. Epub 2019 Apr 10.


Determining stage and anticipating prognosis are the two crucial steps after the diagnosis of a germ-cell cancer that both guide subsequent treatment decisions. This review focuses on metastatic disease, which means germ-cell cancers beyond stage I limited to the testis. In the past, major centers developed separate staging and prognostic classifications for metastatic germ-cell cancer, which heavily impaired communication and comparisons across clinical trials. More recently, the classification system of the International Germ-Cell Cancer Collaborative Group (IGCCCG) has found acceptance worldwide and is currently being updated.

Keywords: classification; germ-cell cancer; prognosis; staging; treatment.

Publication types

  • Review

MeSH terms

  • Humans
  • Male
  • Neoplasm Staging
  • Neoplasms, Germ Cell and Embryonal / diagnosis*
  • Prognosis
  • Testicular Neoplasms / diagnosis*

Supplementary concepts

  • Testicular Germ Cell Tumor