Anatomy, Abdomen and Pelvis, Ovary Corpus Luteum

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan.


The corpus luteum is a vital yet temporary organ that plays a crucial role in fertility during the luteal phase. It is an endocrine structure in females existing within the ovary once the ovarian follicle has released a mature ovum during ovulation. The secretion of hormones from the corpus luteum will stop within 14 days after ovulation if the oocyte is not fertilized, and it then degenerates into a scar within the ovary, known as a corpus albicans. The role of the corpus luteum is the maintenance of a uterine environment that allows for implementation and pregnancy. This occurs by the release of pregnancy-related hormones and regulation of the hypothalamic-pituitary access through inhibition of gonadotropin-releasing hormone from the hypothalamus, which in turn decreases the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) released from the anterior pituitary. The primary hormone produced from the corpus luteum is progesterone, but it also produces inhibin A and estradiol. In the absence of fertilization, the corpus luteum will regress over time. A corpus luteum develops each time a woman ovulates so that a woman will produce a corpus luteum numerous times throughout her lifetime.

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