Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 20 (7)

The Possible Role of Gut Microbiota and Microbial Translocation Profiling During Chemo-Free Treatment of Lymphoid Malignancies


The Possible Role of Gut Microbiota and Microbial Translocation Profiling During Chemo-Free Treatment of Lymphoid Malignancies

Valentina Zuccaro et al. Int J Mol Sci.


The crosstalk between gut microbiota (GM) and the immune system is intense and complex. When dysbiosis occurs, the resulting pro-inflammatory environment can lead to bacterial translocation, systemic immune activation, tissue damage, and cancerogenesis. GM composition seems to impact both the therapeutic activity and the side effects of anticancer treatment; in particular, robust evidence has shown that the GM modulates the response to immunotherapy in patients affected by metastatic melanoma. Despite accumulating knowledge supporting the role of GM composition in lymphomagenesis, unexplored areas still remain. No studies have been designed to investigate GM alteration in patients diagnosed with lymphoproliferative disorders and treated with chemo-free therapies, and the potential association between GM, therapy outcome, and immune-related adverse events has never been analyzed. Additional studies should be considered to create opportunities for a more tailored approach in this set of patients. In this review, we describe the possible role of the GM during chemo-free treatment of lymphoid malignancies.

Keywords: chemo free treatment; gut microbiota; lymphoid malignancies.

Conflict of interest statement

The authors declare no conflict of interest.


Figure 1
Figure 1
Gut microbiome composition in hematopoiesis. SCFAs activates several G-protein-coupled cell surface receptors, such as GPR43, GPR109a and C4, expressed by granulocytes, some myeloid cells epithelial cells, adipocytes, macrophages, and dendritic cells. SCFAs are responsible for promoting the generation of Th1, Th17, and IL-10+ cells and for decreasing the proliferation of T and B cells.

Similar articles

See all similar articles

Cited by 1 article


    1. Glendinning L., Nausch N., Free A., Taylor D.W., Mutapi F. The microbiota and helminths: Sharing the same niche in the human host. Parasitology. 2014;141:1255–1271. doi: 10.1017/S0031182014000699. - DOI - PubMed
    1. Morgan X.C., Huttenhower C. Chapter 12: Human Microbiome Analysis. PLoS Comput. Biol. 2012;8:e1002808 doi: 10.1371/journal.pcbi.1002808. - DOI - PMC - PubMed
    1. Human Microbiome Project—Websites of Interest. [(accessed on 26 December 2018)]; Available online:
    1. Lynch S.V., Pedersen O. The Human Intestinal Microbiome in Health and Disease. N. Engl. J. Med. 2016;375:2369–2379. doi: 10.1056/NEJMra1600266. - DOI - PubMed
    1. Requena T., Martínez-Cuesta M.C., Peláez C. Diet and microbiota linked in health and disease. Food Funct. 2018;9:688–704. doi: 10.1039/C7FO01820G. - DOI - PubMed