A New Approach for Glyco-Functionalization of Collagen-Based Biomaterials

Int J Mol Sci. 2019 Apr 9;20(7):1747. doi: 10.3390/ijms20071747.


The cell microenvironment plays a pivotal role in mediating cell adhesion, survival, and proliferation in physiological and pathological states. The relevance of extracellular matrix (ECM) proteins in cell fate control is an important issue to take into consideration for both tissue engineering and cell biology studies. The glycosylation of ECM proteins remains, however, largely unexplored. In order to investigate the physio-pathological effects of differential ECM glycosylation, the design of affordable chemoselective methods for ECM components glycosylation is desirable. We will describe a new chemoselective glycosylation approach exploitable in aqueous media and on non-protected substrates, allowing rapid access to glyco-functionalized biomaterials.

Keywords: ECM mimetics; biofunctionalization; cell fate; glyco-microenvironment; tissue engineering.

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism*
  • Cell Adhesion / drug effects
  • Cell Culture Techniques / methods*
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival / drug effects
  • Collagen / chemistry
  • Collagen / pharmacology
  • Extracellular Matrix Proteins / metabolism*
  • Glycosylation
  • Humans


  • Biocompatible Materials
  • Extracellular Matrix Proteins
  • Collagen