Interaction between XRCC 1 gene polymorphisms and diabetes on susceptibility to primary open-angle glaucoma

Yanyan Wang; Chenguang Wang; Shounan Qi; Zaoxia Liu; Guanfang Su; Yajuan Zheng

doi:10.1177/1535370219842791

Interaction between XRCC 1 gene polymorphisms and diabetes on susceptibility to primary open-angle glaucoma

Exp Biol Med (Maywood). 2019 May;244(7):588-592. doi: 10.1177/1535370219842791. Epub 2019 Apr 11.

Authors

Yanyan Wang¹, Chenguang Wang¹, Shounan Qi¹, Zaoxia Liu¹, Guanfang Su¹, Yajuan Zheng¹

Affiliation

¹ Department of Ophthalmology, Second Hospital of Jilin University, Jilin University, Changchun 130041, China.

Abstract

Some studies have suggested that diabetes and XRCC gene may be risk factors for glaucoma; however, no studies have focused on the interaction between the XRCC gene and T2DM with respect to POAG risk. Therefore, the present study evaluated the initiative gene-environment interactions in POAG.

Keywords: Primary open angle glaucoma; X-ray cross-complementing group; diabetes; haplotype; interaction; single nucleotide polymorphisms.

MeSH terms

Aged
Aged, 80 and over
Diabetes Mellitus, Type 2 / epidemiology
Diabetes Mellitus, Type 2 / genetics*
Female
Gene-Environment Interaction
Glaucoma, Open-Angle / epidemiology
Glaucoma, Open-Angle / genetics*
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
X-ray Repair Cross Complementing Protein 1 / genetics*

Substances

X-ray Repair Cross Complementing Protein 1
XRCC1 protein, human