Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates

Sci Rep. 2019 Apr 10;9(1):5862. doi: 10.1038/s41598-019-42205-x.


Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and asthma later in childhood, the mechanism(s) of which are still not yet well understood. The objective of this study was to determine the mRNA transcriptome of cord blood mononuclear leukocytes from term neonates to identify key genes and pathways involved in HCA. We found 366 differentially expressed probe IDs with exposure to HCA (198 upregulated, 168 downregulated). These transcriptomes included novel genes and pathways associated with exposure to HCA. The differential gene expression included key genes regulating inflammatory, immune, respiratory and neurological pathways, which may contribute to disorders in those pathways in neonates exposed to HCA. Our data may lead to understanding of the role of key genes and pathways identified on the long-term sequelae related to exposure to HCA, as well as to identifying potential markers and therapies to prevent HCA-associated complications.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Chorioamnionitis / diagnosis*
  • Chorioamnionitis / metabolism
  • Chorioamnionitis / pathology
  • Down-Regulation
  • Extraembryonic Membranes / metabolism
  • Female
  • Fetal Blood / cytology
  • Humans
  • Immunity, Innate
  • Infant, Newborn
  • Leukocytes, Mononuclear / cytology
  • Leukocytes, Mononuclear / metabolism*
  • Pregnancy
  • Signal Transduction / genetics
  • Transcriptome*
  • Up-Regulation