Obstetric and perinatal outcomes of dizygotic twin pregnancies resulting from in vitro fertilization versus spontaneous conception: a retrospective study

Hua Chen; Ying Wan; Haitao Xi; Weijue Su; Jing Cheng; Chunfang Zhu; Jieqiang Lv; Xinmei Wu; Junzhao Zhao

doi:10.7717/peerj.6638

Obstetric and perinatal outcomes of dizygotic twin pregnancies resulting from in vitro fertilization versus spontaneous conception: a retrospective study

PeerJ. 2019 Apr 1:7:e6638. doi: 10.7717/peerj.6638. eCollection 2019.

Authors

Hua Chen¹, Ying Wan², Haitao Xi¹, Weijue Su³, Jing Cheng¹, Chunfang Zhu¹, Jieqiang Lv¹, Xinmei Wu⁴, Junzhao Zhao¹

Affiliations

¹ Reproductive Center, Department of Obstetrics and Gynecology, The 2nd Affliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
² Department of Obstetrics and Gynecology, Jiaxing Maternal and Child Health-care Hospital, Jiaxing, China.
³ Wenzhou Medical University, Wenzhou, China.
⁴ Department of Clinical Laboratory, The 2nd Affliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Abstract

This study was designed to to assess perinatal and neonatal outcomes of dizygotic twin pregnancies conceived naturally or by in vitro fertilization (IVF). After strict selection, the study included 470 dizygotic twin pregnancies. There were 249 resulting from IVF treatments and 221 conceiving spontaneously. After adjusting maternal age and primiparity, the results showed that there were no significant differences between the two groups (P > 0.05) in terms of maternal antenatal complications and neonatal outcomes. In conclusion, our study does not reveal increased risks for pregnancy-related complications and adverse neonatal outcomes in dizygotic twin pregnancies following IVF treatments. With these fundamental data, this study could provide a reference for perinatal care and clinical assisted reproductive technology (ART) treatment and help to inform infertile parents about the potential risks of IVF treatments.

Keywords: In Vitro Fertilization; Obstetric and perinatal outcomes; Spontaneous conception; Twin pregnancy.

Grants and funding

This study was supported by grants from the Zhejiang Provincial Natural Science Foundation (LQ15H040006) and the Wenzhou Municipal Science and Technology Fund (Y20140615 and Y20160008) of China. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.