Malaria Immunity: The Education of an Unnatural Response

Nana K Minkah; Stefan H I Kappe

doi:10.1016/j.chom.2019.03.018

Malaria Immunity: The Education of an Unnatural Response

Cell Host Microbe. 2019 Apr 10;25(4):479-481. doi: 10.1016/j.chom.2019.03.018.

Authors

Nana K Minkah¹, Stefan H I Kappe²

Affiliations

¹ Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave N, Suite 500, Seattle, Washington, USA.
² Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave N, Suite 500, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA. Electronic address: stefan.kappe@seattlechildrens.org.

PMID: 30974081
DOI: 10.1016/j.chom.2019.03.018

Abstract

In this issue of Cell Host & Microbe, Kurup et al. report that infection of the liver by Plasmodium parasites promotes the recruitment of dendritic cells that acquire and present parasite antigen from infected hepatocytes. These cells then prime parasite-specific CD8 T cells in liver-draining lymph nodes.

Publication types

Comment

MeSH terms

Antigens, Protozoan / immunology
CD8-Positive T-Lymphocytes / immunology
Hepatocytes / parasitology
Humans
Liver / parasitology
Malaria / parasitology*
Monocytes
Plasmodium berghei / immunology*

Substances

Antigens, Protozoan