Complement Seals a Virus to Block Infection

Jason G Smith; Glen R Nemerow

doi:10.1016/j.chom.2019.03.010

Complement Seals a Virus to Block Infection

Cell Host Microbe. 2019 Apr 10;25(4):482-483. doi: 10.1016/j.chom.2019.03.010.

Authors

Jason G Smith¹, Glen R Nemerow²

Affiliations

¹ Department of Microbiology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA. Electronic address: jgsmith2@uw.edu.
² Department of Immunology and Microbiology, The Scripps Research Institute, 10660 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gnemerow@scripps.edu.

PMID: 30974082
DOI: 10.1016/j.chom.2019.03.010

Abstract

In this issue of Cell Host & Microbe, Bottermann et al. (2019) reveal that complement component C4 inhibits adenovirus by inactivating the virus capsid through mechanisms requiring antibody engagement, but not late-acting complement pathways. This antiviral function likely broadly impacts non-enveloped viruses and may help illuminate the process of virus disassembly.

Publication types

Comment

MeSH terms

Capsid Proteins
Capsid*
Complement C4*
Complement System Proteins
Virion

Substances

Capsid Proteins
Complement C4
Complement System Proteins