Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference

Antiviral Res. 2019 Jul;167:45-67. doi: 10.1016/j.antiviral.2019.04.006. Epub 2019 Apr 8.

Abstract

The International Society for Influenza and other Respiratory Virus Diseases held its 6th Antiviral Group (isirv-AVG) conference in Rockville, Maryland, November 13-15, 2018. The three-day program was focused on therapeutics towards seasonal and pandemic influenza, respiratory syncytial virus, coronaviruses including MERS-CoV and SARS-CoV, human rhinovirus, and other respiratory viruses. Updates were presented on several influenza antivirals including baloxavir, CC-42344, VIS410, immunoglobulin, immune plasma, MHAA4549A, pimodivir (JNJ-63623872), umifenovir, and HA minibinders; RSV antivirals including presatovir (GS-5806), ziresovir (AK0529), lumicitabine (ALS-008176), JNJ-53718678, JNJ-64417184, and EDP-938; broad spectrum antivirals such as favipiravir, VH244, remdesivir, and EIDD-1931/EIDD-2801; and host directed strategies including nitazoxanide, eritoran, and diltiazem. Other topics included considerations of novel endpoints such as ordinal scales and patient reported outcomes (PRO), and study design issues, and other regulatory considerations for antiviral drug development. The aim of this report is to provide a summary of the presentations given at this meeting.

Keywords: Antiviral therapy; Coronavirus; Host-directed therapeutics; Influenza; Respiratory syncytial virus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / pharmacology
  • Alanine / analogs & derivatives
  • Alanine / pharmacology
  • Antiviral Agents / pharmacology*
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / transmission
  • Humans
  • Influenza, Human / diagnosis
  • Influenza, Human / drug therapy
  • Influenza, Human / transmission
  • Pandemics
  • Respiratory Syncytial Virus, Human / drug effects
  • Respiratory Syncytial Virus, Human / genetics
  • Respiratory Syncytial Virus, Human / pathogenicity
  • Respiratory Tract Infections / therapy*
  • Respiratory Tract Infections / virology*

Substances

  • Antiviral Agents
  • remdesivir
  • Adenosine Monophosphate
  • Alanine