Purpose of review: We reviewed the available literature on observational studies, meta-analyses, expert reports, and umbrella reviews. Here, we summarize the latest findings on the association between coffee intake and liver cancer risk.
Recent findings: Most observational studies and meta-analyses show a protective effect of coffee intake on liver cancer risk, with dose-responsiveness and across different populations, and regardless of hepatitis virus infection status. Risk reduction by coffee consumption has also been observed for chronic liver diseases. Potential mechanisms include the effect of a number of bioactive compounds such as caffeine, chlorogenic acids, phenolic compounds and diterpenes; antioxidant properties; induction of defense mechanisms; and anti-inflammatory properties. Other potential mechanisms include improvement in insulin sensitivity and prevention of metabolic syndrome and diabetes. Accumulated evidence, with consistency across study designs and populations, suggests that coffee intake probably reduces the risk of liver cancer. Future research should aim to elucidate the mechanism of this preventive effect with establishing the causality of an association.
Keywords: Causality; Coffee; Dose-response; Epidemiology; Liver cancer; Mechanism; Reduced risk.
Coffee Drinking and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational StudiesLG Zhao et al. BMC Cancer 20 (1), 101. PMID 32024485.There is highly suggestive evidence for an inverse association between coffee intake and risk of liver and endometrial cancer. Further research is needed to provide more …
Coffee Consumption and Health: Umbrella Review of Meta-Analyses of Multiple Health OutcomesR Poole et al. BMJ 359, j5024. PMID 29167102. - ReviewObjectives To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes.Design Umbrella review of the evidence …
Chronic Inflammatory Liver Diseases and Coffee IntakeF Contaldo et al. Curr Opin Clin Nutr Metab Care 22 (5), 389-392. PMID 31219824.A regular coffee consumption may have preventive healthy effects, especially if consumed without added sugars. Certainly, coffee consumption should not be prohibited in i …
Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose-Response Meta-Analysis of Prospective Cohort StudiesJ Godos et al. Nutrients 9 (9). PMID 28846640.The findings suggest that increased coffee consumption is associated with decreased risk of liver cancer, but not BTC.
Drinking for Protection? Epidemiological and Experimental Evidence on the Beneficial Effects of Coffee or Major Coffee Compounds Against Gastrointestinal and Liver CarcinogenesisGR Romualdo et al. Food Res Int 123, 567-589. PMID 31285007. - ReviewRecent meta-analyses indicate that coffee consumption reduces the risk for digestive tract (oral, esophageal, gastric and colorectal) and, especially, liver cancer. Coffe …
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Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration CurveVM Mendes et al. Molecules 24 (16). PMID 31394755.Caffeine is one of the most widely consumed psycho-stimulants. The study of the beneficial effects of caffeine consumption to decrease the risk of developing several neur …