Putting a New Spin on It: Gradient Centrifugation for Analytical and Preparative Applications

Chemistry. 2019 Aug 1;25(43):10026-10032. doi: 10.1002/chem.201900974. Epub 2019 Jun 3.


Gradient centrifugation is an important technique in chemistry, biology, materials science and engineering. It has big potential beyond the well-known centrifugation for separation of molecules and particles. Various possibilities for special analysis and separation of particles, but also preparative applications like the production of gradient materials and controlled polymerizations exist. In all examples, a gradient of physical and/or chemical properties is generated by centrifugation and used for the further application. In this Concept article, selected examples of gradient centrifugation are presented, to show important developments in the field and discuss their applications, potential, and limitations. It concludes by analysing future trends of gradient centrifugation that are relevant for academic and industrial usage.

Keywords: centrifugation; gradients; materials science; polymerization; separation.

MeSH terms

  • Centrifugation, Density Gradient / methods*
  • Gold / chemistry
  • Metal Nanoparticles / chemistry
  • Polymers / chemistry


  • Polymers
  • Gold

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