Genetic diversity of the potentially therapeutic tapeworm Hymenolepis diminuta (Cestoda: Cyclophyllidea)

Parasitol Int. 2019 Aug;71:121-125. doi: 10.1016/j.parint.2019.04.009. Epub 2019 Apr 11.


The cestode Hymenolepis diminuta is highly prevalent in wild rat populations and has also been observed rarely in humans, generally causing no apparent harm. The organism has been studied for decades in the laboratory, and its colonization of laboratory rats has recently been shown as protective against some inflammation-associated disorders. Recently, H. diminuta has become a leading candidate for helminth therapy, an emerging method of "biota enrichment" used to treat or prevent inflammatory diseases of humans in Western society. While most of the experimental isolates of H. diminuta are identified based on typical morphological features, hymenolepidid tapeworms may represent complexes of cryptic species as detected by molecular sequence data. In the present study, we explored the diversity of laboratory-kept strains using partial sequences of two genes (lsrDNA and cox1) and determined that H. diminuta isolates currently considered for therapeutic purposes in the US and Europe belong to a single, genetically nearly uniform lineage, showing only little genetic deviation from wild-caught isolates.

Keywords: Genetic diversity; Helminth-therapy; Hymenolepis diminuta; Laboratory isolates.

MeSH terms

  • Animals
  • Animals, Laboratory / parasitology*
  • Cestoda / genetics*
  • Cestoda / physiology
  • Cestode Infections
  • Electron Transport Complex IV / genetics
  • Genetic Variation*
  • Inflammation / therapy*
  • Phylogeny
  • Rats / parasitology
  • Ribosome Subunits, Large, Eukaryotic / genetics
  • Sequence Analysis, DNA


  • Electron Transport Complex IV