Relationship between neuropsychological behavior and brain white matter in first-episode psychosis

Schizophr Res. 2019 Jun:208:49-54. doi: 10.1016/j.schres.2019.04.010. Epub 2019 Apr 13.


We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).

Keywords: Cognition; DTI; First-episode psychosis; MRI; Schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cognitive Dysfunction / etiology
  • Cognitive Dysfunction / physiopathology*
  • Cohort Studies
  • Diffusion Tensor Imaging
  • Female
  • Humans
  • Male
  • Psychotic Disorders / complications
  • Psychotic Disorders / diagnostic imaging
  • Psychotic Disorders / pathology*
  • Psychotic Disorders / physiopathology*
  • Schizophrenia / complications
  • Schizophrenia / diagnostic imaging
  • Schizophrenia / pathology*
  • Schizophrenia / physiopathology*
  • White Matter / diagnostic imaging
  • White Matter / pathology*
  • Young Adult