Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement

Br J Haematol. 2019 Aug;186(4):e91-e94. doi: 10.1111/bjh.15922. Epub 2019 Apr 15.

Authors

Marek Mraz^{1

2}, Sarka Pospisilova²

Affiliations

¹ Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic.
² Department of Internal Medicine, Haematology and Oncology, University Hospital Brno and Faculty of Medicine MU, Brno, Czech Republic.

PMID: 30989644
DOI: 10.1111/bjh.15922

No abstract available

Keywords: array CGH; chronic lymphocytic leukaemia; deletion; lambda light chain; loss of 22q11.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Neoplasm / genetics
Biomarkers, Tumor
Chromosome Deletion*
Chromosomes, Human, Pair 22*
Comparative Genomic Hybridization
Genetic Loci*
Humans
Immunoglobulin Light Chains / genetics
Immunoglobulin lambda-Chains / genetics
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Repressor Proteins / genetics

Substances

Antigens, Neoplasm
Biomarkers, Tumor
Immunoglobulin Light Chains
Immunoglobulin lambda-Chains
PRAME protein, human
Repressor Proteins
ZNF280B protein, human