Molecular recognition of nucleosomes by binding partners

Curr Opin Struct Biol. 2019 Jun:56:164-170. doi: 10.1016/ Epub 2019 Apr 13.


Nucleosomes represent the elementary units of chromatin packing and hubs in epigenetic signaling pathways. Across the chromatin and over the lifetime of the eukaryotic cell, nucleosomes experience a broad repertoire of alterations that affect their structure and binding with various chromatin factors. Dynamics of the histone core, nucleosomal and linker DNA, and intrinsic disorder of histone tails add further complexity to the nucleosome interaction landscape. In light of our understanding through the growing number of experimental and computational studies, we review the emerging patterns of molecular recognition of nucleosomes by their binding partners and assess the basic mechanisms of its regulation.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Humans
  • Intrinsically Disordered Proteins / metabolism
  • Nucleosomes / metabolism*


  • Intrinsically Disordered Proteins
  • Nucleosomes