Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice

Nutrients. 2019 Apr 15;11(4):852. doi: 10.3390/nu11040852.


The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in theregulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHAand low or high content of sucrose impact on metabolism in mice deficient for elongation of verylong-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. Wefound that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, highfat challenge significantly increased body weight. This diet affected the triglyceride rich lipoproteinfraction of plasma lipoproteins and changed the expression of several genes involved in lipidmetabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals issynergistically influenced by DHA dietary and sucrose content.

Keywords: DHA deficiency; DHA supplementation; ELOVL2; high sucrose diet.

MeSH terms

  • Acetyltransferases / genetics
  • Acetyltransferases / metabolism
  • Adipose Tissue, White / drug effects*
  • Adipose Tissue, White / metabolism
  • Animals
  • Diet, High-Fat
  • Dietary Fats / administration & dosage
  • Dietary Fats / blood
  • Dietary Sucrose / pharmacology*
  • Docosahexaenoic Acids / deficiency
  • Docosahexaenoic Acids / pharmacology*
  • Fatty Acid Elongases
  • Lipogenesis / drug effects*
  • Lipogenesis / genetics
  • Lipoproteins / blood
  • Mice, Knockout
  • Triglycerides / blood
  • Weight Gain / drug effects*


  • Dietary Fats
  • Dietary Sucrose
  • ELOVL2 protein, mouse
  • Lipoproteins
  • Triglycerides
  • Docosahexaenoic Acids
  • Acetyltransferases
  • Fatty Acid Elongases