Anti- N-methyl-d-aspartate receptor encephalitis in an older patient presenting with a rapid onset of delusions and amnesia

BMJ Case Rep. 2019 Apr 15;12(4):e228512. doi: 10.1136/bcr-2018-228512.


We present the case of a 77-year-old patient with a rapid onset of delusions, amnesia, agitation, insomnia and no previous psychiatric history, who was diagnosed with anti-N-methyl-d-aspartate receptor encephalitis. This case report highlights the importance of including autoimmune encephalitis in the differential diagnosis of older patients presenting with rapid onset psychiatric episodes.

Keywords: neurology (drugs and medicines); psychiatry (drugs and medicines).

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Amnesia / etiology
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / cerebrospinal fluid
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / diagnosis*
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / drug therapy
  • Delusions / etiology
  • Diagnosis, Differential
  • Humans
  • Immunoglobulin A / administration & dosage
  • Male
  • Psychomotor Agitation / etiology
  • Receptors, N-Methyl-D-Aspartate / immunology*


  • Immunoglobulin A
  • Receptors, N-Methyl-D-Aspartate