Synthesis of acylglycerol derivatives by mechanochemistry

Karen J Ardila-Fierro; Andrij Pich; Marc Spehr; José G Hernández; Carsten Bolm

doi:10.3762/bjoc.15.78

Synthesis of acylglycerol derivatives by mechanochemistry

Beilstein J Org Chem. 2019 Mar 29:15:811-817. doi: 10.3762/bjoc.15.78. eCollection 2019.

Authors

Karen J Ardila-Fierro¹, Andrij Pich^{2

3

4}, Marc Spehr⁵, José G Hernández¹, Carsten Bolm¹

Affiliations

¹ Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.
² Functional and Interactive Polymers, Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany.
³ DWI-Leibniz-Institute for Interactive Materials, Forckenbeckstrasse 50, D-52074 Aachen, Germany.
⁴ Aachen Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Brightlands Chemelot Campus, Urmonderbaan22, 6167 RD Geleen, The Netherlands.
⁵ Department of Chemosensation, Institute for Biology II, RWTH Aachen University, D-52074 Aachen, Germany.

Abstract

In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.

Keywords: ball mill; coumarin; diacylglycerols; lipids; mechanochemistry.