Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review

Clin Case Rep. 2019 Feb 19;7(4):638-643. doi: 10.1002/ccr3.2026. eCollection 2019 Apr.


Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG) screening could be a valuable tool for detecting peripheral neurotoxicity.

Keywords: F wave; chemotherapy; methotrexate; neurotoxicity; polyradiculoneuropathy.

Publication types

  • Case Reports