Co(II)-Catalyzed Regioselective Pyridine C-H Coupling with Diazoacetates

Haisheng Xie; Youxiang Shao; Jiao Gui; Jianyong Lan; Zhipeng Liu; Zhuofeng Ke; Yuanfu Deng; Huanfeng Jiang; Wei Zeng

doi:10.1021/acs.orglett.9b01196

Co(II)-Catalyzed Regioselective Pyridine C-H Coupling with Diazoacetates

Org Lett. 2019 May 3;21(9):3427-3430. doi: 10.1021/acs.orglett.9b01196. Epub 2019 Apr 18.

Authors

Haisheng Xie¹, Youxiang Shao², Jiao Gui¹, Jianyong Lan¹, Zhipeng Liu¹, Zhuofeng Ke², Yuanfu Deng¹, Huanfeng Jiang¹, Wei Zeng¹

Affiliations

¹ Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510641 , China.
² School of Materials Science & Engineering, PCFM Lab , Sun Yat-sen University , Guangzhou 510275 , China.

PMID: 30998018
DOI: 10.1021/acs.orglett.9b01196

Abstract

A Co(II)-catalyzed pyridyl C-H bond carbenoid insertion with α-diazoacetates has been realized. This transformation features a highly regioselective C-C bond formation at the C3-position of pyridines, providing an efficient access to diverse α-aryl-α-pyridylacetates.

Publication types

Research Support, Non-U.S. Gov't