The Panacea of Human Aging: Calorie Restriction Versus Exercise

Exerc Sport Sci Rev. 2019 Jul;47(3):169-175. doi: 10.1249/JES.0000000000000193.


Primary aging is the progressive decline in health and fitness and depends on metabolic rate and oxidative stress. Untoward changes in body composition and metabolic function characterize secondary aging. We hypothesize that both exercise and calorie restriction (CR) improve secondary aging, but only CR improves primary. However, CR followed with exercise is a superior strategy to maintain overall health and quality of life with age.

Trial registration: NCT00427193 NCT02695511.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adiposity / physiology
  • Aging / physiology*
  • Caloric Restriction*
  • Energy Metabolism
  • Exercise / physiology*
  • Humans
  • Longevity / physiology
  • Quality of Life

Associated data