Effect of a simulated 3,048 meter altitude on the single-breath transfer factor

Bull Eur Physiopathol Respir. 1986 Sep-Oct;22(5):429-31.


The single-breath transfer factor (TLCO) was measured in ten healthy subjects at sea level and at a simulated altitude of 3,048 m. Measurements were made at sea level using 21% oxygen and at altitude using both 21% and 31% oxygen in the test gas. At 3,048 m altitude (PB = 69.7 kPa), the mean TLCO increased 14% or about 2.3% per kPa (0.3% per mmHg) decrease in inspired oxygen pressure. Our data also suggests that altering the test gas oxygen concentration to account for the change in PAO2 due to altitude results in a TLCO equivalent to that obtained at sea level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Altitude*
  • Breath Tests
  • Carbon Dioxide
  • Carbon Monoxide
  • Female
  • Humans
  • Male
  • Oxygen
  • Pulmonary Diffusing Capacity*


  • Carbon Dioxide
  • Carbon Monoxide
  • Oxygen