Chronic Kidney Disease in Agricultural Communities

Am J Med. 2019 Oct;132(10):e727-e732. doi: 10.1016/j.amjmed.2019.03.036. Epub 2019 Apr 15.


Patients residing in agricultural communities have a high risk of developing chronic kidney disease. In the Great Plains, geo-environmental risk factors (eg, variable climate, temperature, air quality, water quality, and drought) combine with agro-environmental risk factors (eg, exposure to fertilizers, soil conditioners, herbicides, fungicides, and pesticides) to increase risk for toxic nephropathy. However, research defining the specific influence of agricultural chemicals on the progression of kidney disease in rural communities has been somewhat limited. By linking retrospective clinical data within electronic medical records to environmental data from sources like US Environmental Protection Agency, analytical models are beginning to provide insight into the impact of agricultural practices on the rate of progression for kidney disease in rural communities.

Keywords: Heavy metal; Herbicide; Pesticide; Toxic nephropathy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Agriculture / methods
  • Agriculture / trends*
  • Glycine / adverse effects
  • Glycine / analogs & derivatives
  • Humans
  • North Dakota / epidemiology
  • Occupational Exposure / adverse effects
  • Public Health / standards
  • Public Health / trends
  • Renal Insufficiency, Chronic / epidemiology
  • Renal Insufficiency, Chronic / etiology*
  • Retrospective Studies
  • South Dakota / epidemiology


  • glyphosate
  • Glycine